“In 3xTg mice, long-term FMD cycles reduce hippocampal amyloid beta load and hyperphosphorylated tau, enhance genesis of neural stem cells, decrease microglia number, and reduce expression of neuroinflammatory genes, including superoxide-generating NADPH oxidase (Nox2).”
It concludes: “Clinical data indicate that FMD cycles are feasible and generally safe in a small group of AD patients.
“These results indicate that FMD cycles delay cognitive decline in AD models in part by reducing neuroinflammation and/or superoxide production in the brain.”
The team also analysed data from a small clinical trial that studied a fasting diet on humans with mild cognitive impairment or Alzheimer’s disease.
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