Margolyes, 79, appeared on the ITV show via a video link from her home in Italy, where she criticised Boris Johnson, Donald Trump and those who oppose the coronavirus vaccination.
Despite being on the show for a brief time, Margolyes – who is known for her zaniness – refused to hold back to the joy of viewers.
“Of course one must have the vaccine,” she told co-host Susanna Reid: “Those anti-vaxxers are nuts. They need their heads seen to.”
She continued: “I’m hoping that I get a vaccine as soon as possible. I’ll be 80 in May and i may be able to have it in Italy before I come [back], but I’m not coming to England until it’s safe to go.
“You’ve got that clown in charge there that I didn’t vote for, and I’m holding him responsible,” she said.
Elsewhere, when describing Trump, she said that he “ends with ‘hole’ [and] starts with ‘A’”.
One viewer reacted to her appearance by stating: “Miriam Margolyes is gold in human form. The woman is wonderful.”
“Miriam Margolyes should be running this country,” another added.
One stated: “Called Trump an a**hole and Johnson a clown. Finger on the pulse there.”